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During the first step a large movement between C-domain and N-domain occurs, which closes the cleft and brings C4 of the nicotinamide ring and the alpha carbon of the substrate into the correct position for a hydride transfer (1)

Uccellatore A, Genovese S, Dicembrini I, Mannucci E, Ceriello A

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Further research is needed to elucidate the long-term effects and mechanisms of IF in the management of RA